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Objective@#To investigate current status of screen-time in 2-6 years old preschoolers in Beijing, and to describe associated factors of high screen time, and to provide a reference for making interventional measures to prevent and control short-sightness.@*Methods@#A total of 366 preschoolers were chosen through convenience sampling from 5 kindergartens in Beijing urban and rural areas. Questionnaire survey was administered to parents regarding child screen-time.@*Results@#The average screen time of the preschool children in Beijing was (120.5±78.5)min/d, and the rate of high screen time was 75.8%. The average screen time during weekdays was (92.4±72.8) min/d, which was less than the average screen time at weekends (192.4±117.0) min/d. Logistic regression analysis showed that age (OR=1.69, 95%CI=1.19-2.38, P＜0.05) and without an habit of exercise among parents (OR=3.05, 95%CI=1.50-6.19, P＜0.05) were positively associated with, and being girl was the negatively associated with high screen-time (OR=0.49, 95%CI=0.25-0.99, P＜0.05).@*Conclusion@#A large proportion of the preschool children aged 2-6 in Beijing have too long screen time, especailly during weekend, and gender, age, parental habit of exercising and so on have impacts on their screen time. Therefore, the education and prevention work should be conducted to reduce their screen time.
RESUMO
Objective By taking usage of bioinformatics screening methods,this medical research aimed at exploring how the miRNAs in endothelial progenitor cell exosomes relate to the regulation of angiogenesis.Methods miRNAs in endothelial progenitor cells exosomes and angiogenesis-related miRNA was intersected from the existing database to obtain the candidates of miRNA molecules related to angiogenesis in endothelial progenitor exosomes.Results 160 and 50 miRNAs in endothelial progenitor cell candidates were obtained through experimental data analysis and literature searching respectively.600 candidates of angiogenesis-related miRNAs were obtained through literature searching;the top 20 with the highest frequency were selected out.Finally,9 miRNA candidates (miR-126,miR-21,miR-221,miR-92a,miR-199a,miR-210,miR-214,miR-155,miR-146a) that may be highly expressed in endothelial progenitor exosomes and associated with angiogenesis were obtained for the following research.Conclusions Based on data analysis and literature searching,bioinformatics could screen out the target miRNAs for follow-up studies easily and reliably,it is worthy to be widely applied and popularized.
